SidaGhanaV1, Main, Exploration, bibRecord, 000B12

Prevalence of Persistent and Latent Viruses in Untreated Patients Infected With HIV-1 From Ghana, West Africa

Identifieur interne : 000B12 ( Main/Exploration ); précédent : 000B11; suivant : 000B13

Prevalence of Persistent and Latent Viruses in Untreated Patients Infected With HIV-1 From Ghana, West Africa

Auteurs : Lara Isobel Compston [Royaume-Uni] ; CHENGYAO LI [République populaire de Chine] ; Francis Sarkodie [Ghana] ; Shirley Owusu-Ofori [Ghana] ; Ohene Opare-Sem [Ghana] ; Jean-Pierre Allain [Royaume-Uni]

Source :

Journal of medical virology [ 0146-6615 ] ; 2009.

RBID : Pascal:09-0421865

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Herpesviridae, Virus hépatite B, Virus hépatite G, Prévalence, Epidémiologie, Ghana, Afrique Ouest, Hépatite virale B, Parvovirus, Afrique subsaharienne, SIDA, Immunodéficit.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- AIDS, Epidemiology, Ghana, Hepatitis B virus, Hepatitis G virus, Herpesviridae, Human immunodeficiency virus, Immune deficiency, Parvovirus, Prevalence, Sub-Saharan Africa, Viral hepatitis B, West Africa.

Abstract

Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/ AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV-C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P<0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P<0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P<0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV-1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P≤0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (>90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV-8 (asymptomatic and symptomatic HIV).

Affiliations:

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Le document en format XML

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<term>Human immunodeficiency virus</term>
<term>Immune deficiency</term>
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<term>Afrique Ouest</term>
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<front><div type="abstract" xml:lang="en">Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/ AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV-C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P<0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P<0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P<0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV-1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P≤0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (>90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV-8 (asymptomatic and symptomatic HIV).</div>
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<name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name>
<name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
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	Le SIDA au Ghana (serveur d'exploration)
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Le SIDA au Ghana (serveur d'exploration)

Prevalence of Persistent and Latent Viruses in Untreated Patients Infected With HIV-1 From Ghana, West Africa

Prevalence of Persistent and Latent Viruses in Untreated Patients Infected With HIV-1 From Ghana, West Africa

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri